TABLE 1.
Modes of single cell migration.
| Migration mode | Classification | Protrusion type | MMP required? | NMII required? | Cell-matrix adhesion required? |
|---|---|---|---|---|---|
| 2D lamellipodia | Not applicable | Lamellipodia | No | No | Yes |
| Nuclear piston | Path-generating | Lobopodia | No | Yes | Yes |
| Mesenchymal | Path-generating | Lamellipodia | Yes | Yes | Yes |
| Unstable bleb amoeboid | Pathfinding | Small, dynamic blebs | No | Yes | Yes |
| Stable bleb amoeboid (A1) | Pathfinding | Large, stable blebs | No | Yes | No |
| Rapid amoeboid (A2) | Pathfinding | Small lamellipodia? | No | No | No |
| Osmotic engine | Pathfinding | Not determined | Not determined | No | No |