Table 2.
Information on 41 vital targets of ZQFZ granule against NSCLC.
| Number | Uniprot ID | Gene symbol | Description | Degree |
|---|---|---|---|---|
| 1 | P05231 | IL-6 | Interleukin-6 | 40 |
| 2 | P00533 | EGFR | Epidermal growth factor receptor | 39 |
| 3 | P35222 | CTNNB1 | Catenin beta-1 | 39 |
| 4 | P12931 | SRC | Proto-oncogenetyrosine-protein kinase Src | 39 |
| 5 | P01375 | TNF | Tumor necrosis factor | 39 |
| 6 | P40763 | STAT3 | Signal transducer and activator of transcription 3 | 38 |
| 7 | P42574 | CASP3 | Caspase-3 | 37 |
| 8 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 35 |
| 9 | P24385 | CCND1 | G1/S-specific cyclin-D1 | 34 |
| 10 | P03372 | ESR1 | Estrogen receptor alpha | 34 |
| 11 | P04626 | ERBB2 | Receptor protein-tyrosine kinase ERBB-2 | 33 |
| 12 | P35354 | PTGS2 | Prostaglandin G/H synthase 2 | 32 |
| 13 | P45983 | MAPK8 | Mitogen-activated protein kinase 8 | 31 |
| 14 | P14780 | MMP9 | Matrix metalloproteinase 9 | 31 |
| 15 | P60568 | IL2 | Interleukin-2 | 29 |
| 16 | Q04206 | RELA | Nuclear factor NF-kappa B p65 subunit | 28 |
| 17 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 28 |
| 18 | P08253 | MMP2 | Matrix metalloproteinase 2 | 27 |
| 19 | P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | 27 |
| 20 | O00206 | TLR4 | Toll-like receptor 4 | 26 |
| 21 | P10721 | KIT | Mast/stem cell growth factor receptor kit | 25 |
| 22 | P10275 | AR | Androgen receptor | 25 |
| 23 | P08575 | PTPRC | Receptor-typetyrosine-protein phosphatase C | 25 |
| 24 | P05362 | ICAM1 | Intercellular adhesion molecule 1 | 25 |
| 25 | P04150 | NR3C1 | Glucocorticoid receptor | 24 |
| 26 | P00519 | ABL1 | Tyrosine-protein kinase ABL1 | 24 |
| 27 | Q07820 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | 24 |
| 28 | P09619 | PDGFRB | Platelet-derived growth factor receptor beta | 23 |
| 29 | P05067 | APP | Amyloid-beta precursor protein | 22 |
| 30 | P08581 | MET | Hepatocyte growth factor receptor | 22 |
| 31 | P06239 | LCK | Tyrosine-protein kinase LCK | 21 |
| 32 | P06241 | FYN | Tyrosine-protein kinase FYN | 21 |
| 33 | Q06124 | PTPN11 | Protein-tyrosine phosphatase 2C | 20 |
| 34 | P11802 | CDK4 | Cyclin-dependent kinase 4 | 19 |
| 35 | P09874 | PARP1 | Poly [ADP-ribose]polymerase-1 | 19 |
| 36 | Q07869 | PPARA | Peroxisome proliferator-activated receptor alpha | 19 |
| 37 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | 17 |
| 38 | P35869 | AHR | Aryl hydrocarbon receptor | 17 |
| 39 | P11511 | CYP19A1 | Cytochrome P450 19A1 | 16 |
| 40 | P00749 | PLAU | Urokinase-type plasminogen activator | 16 |
| 41 | P12821 | ACE | Angiotensin-converting enzyme | 14 |