Skip to main content
. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Nat Chem Biol. 2022 Jun 27;18(12):1298–1306. doi: 10.1038/s41589-022-01046-y

Figure 4.

Figure 4

Chemical specificity for small molecules in condensates.

A) Cisplatin-TR selectively concentrates in specific condensates in droplet partitioning assays.36

B) Changes in amino acid composition of a condensate forming protein can abrogate small molecule partitioning behavior without affecting condensate formation. The ability of droplets formed by the MED1 protein of the Mediator complex to concentrate cisplatin is reduced with the replacement of aromatic residues with alanine residues.36.

C) Model depicting how specific local chemical environments within a condensate may influence cisplatin partitioning and concentration within a transcriptional condensate.