Fig. 6.
Rbm20I538T knock-in mice do not show cardiac dysfunction. A Heart/body weight ratio at the age of 12 weeks. n = 6 each. B Representative images of H&E staining and Masson’s trichrome staining at the age of 12 weeks. Scale bars, 4 mm. C qRT-PCR analysis of genes related to cardiac fibrosis at the age of 12 weeks. n = 6 each. D Measured values of LVFS, LVDd, and LVPWth by UCG at the age of 12 weeks. n = 6 each. E Representative images of UCG at the age of 12 weeks. F Gene expression of Nppa and Nppb in the heart assessed by qRT-PCR at the age of 12 weeks. n = 6 each. Error bars indicate 95% confidence interval. Tukey’s multiple comparison test