TABLE 2.

Murine antibody response to NTHi 9274 LOS elicited by conjugates

Immunogen	Injection no.	GM (±SD range) ELISA unitsa for:
		IgG	IgM
OS-OMP	1	2 (1–4)	1 (1–2)
	2	2 (1–3)	2 (1–5)
	3	1 (1–2)	1 (1–2)
OS-OMP + adjuvant	1	2 (1–3)	2 (1–5)+
	2	3 (2–7)	8 (6–12)++
	3	3 (2–5)	7 (4–12)
dLOS-OMP	1	6 (3–10)+	6 (3–10)+
	2	269 (60–1,202)++	59 (23–148)++
	3	417 (145–1,202)	16 (6–40)
dLOS-OMP + adjuvant	1	42 (19–91)+	27 (10–76)+
	2	912 (214–3,891)++	132 (38–475)++
	3	5,248 (1,514–18,197)	47 (14–155)
dLOS + OMP	1	2 (1–3)+	3 (1–6)
	2	7 (3–16)++	7 (5–12)
	3	5 (2–11)	8 (4–15)
dLOS-TT	1	3 (1–5)+	1 (1–2)+
	2	16 (4–71)++	9 (4–22)++
	3	63 (16–246)	3 (1–5)
dLOS-TT + adjuvant	1	275 (123–617)+	52 (24–115)+
	2	1,122 (447–2,818)++	141 (65–309)++
	3	3,020 (1,072–8,511)	178 (85–372)
dLOS + TT	1	1 (1–2)	1 (1–2)
	2	2 (1–4)	2 (1–4)
	3	3 (1–14)	2 (1–3)

^aBased on a reference serum against strain 9274 (2,400 or 800 U for IgG or IgM) and 9274 LOS as a coating antigen (10 μg/ml). Presera were ≤3 U for IgG and IgM. Symbols: + versus ++, P < 0.01. GM, geometric mean.