TABLE 4.

Murine antibody response to OMP or TT elicited by conjugates

Immunogen	Injection no.	GM (±SD range) ELISA unitsa for:
		IgG	IgM
OS-OMP	1	19 (9–41)+	2 (1–3)+
	2	178 (43–741)++	4 (2–6)++
	3	316 (115–891)	3 (2–5)
OS-OMP + adjuvant	1	37 (14–102)+	2 (2–4)+
	2	1,698 (398–7,244)++	20 (12–33)++
	3	3,467 (1,349–8,913)	16 (9–28)
dLOS-OMP	1	17 (10–31)+	1 (1–2)+
	2	912 (407–2,042)++	59 (35–100)++
	3	1,000 (631–1,585)	13 (5–36)
dLOS-OMP + adjuvant	1	65 (31–135)+	27 (16–46)+
	2	3,162 (1,288–7,763)++	72 (51–102)++
	3	3,388 (1,995–5,754)	53 (30–93)
dLOS + OMP	1	16 (9–28)+	3 (2–4)*
	2	468 (214–1,023)++	10 (2–62)**
	3	1,259 (575–2,754)	8 (1–59)
dLOS-TT	1	2 (1–6)+	1 (1–2)
	2	30 (8–110)	2 (1–3)
	3	275 (123–617)++	3 (1–7)
dLOS-TT + adjuvant	1	18 (4–83)+	8 (6–11)+
	2	912 (110–7,586)++	24 (9–63)++
	3	5,248 (3,311–8,318)	27 (12–62)
dLOS + TT	1	7 (4–15)+	2 (1–4)
	2	81 (39–170)++	2 (1–4)
	3	178 (50–631)	5 (12–20)

^aBased on a reference serum against OMP (2,430 or 90 U for IgG or IgM) or TT (810 or 30 U for IgG or IgM). OMP (10 μg/ml) or TT (5 μg/ml) was used as a coating antigen. Presera were ≤3 U for each Ig. Symbols: ∗ versus ∗∗, P < 0.05; + versus ++, P < 0.01. GM, geometric mean.