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(a) Overlay of the HDAC6-10h complex (chain B, light gray; chain D, dark gray; PDB 7U8Z) with the HDAC6 complex with the non-fluorinated inhibitor (light pink; PDB 6DVN). The catalytic Zn2+ ion is shown as a grey sphere and metal coordination is indicated by solid black lines. (b) Overlay of the HDAC6-10h complex (chain B, light gray; chain D, dark gray; PDB 7U8Z) with an inhibitor containing a meta-difluorophenyl linker (PDB 7O2R).
