Table 2.

Cytotoxicities of 10a-p against selected leukemia cell lines. Vorinostat, HPOB, and ricolinostat were used as controls.

Compound	R1	R2	HAL01 IC50 [μM]	HL60 IC50 [μM]	Jurkat IC50 [μM]
10a	c-Hexyl	3,5-Me	3.10 ± 0.91	2.47 ± 2.05	3.91 ± 0.67
10b	c -Hexyl	4-NMe2	1.05±0.28	0.494±0.126	0.946±0.087
10c	c -Hexyl	2-F	11.8±5.14	6.79±3.31	8.97±1.73
10d	c -Hexyl	2-Me	9.93±1.55	7.72±3.45	9.47±3.55
10e	c -Hexyl	2-OMe	>25	12.3±9.70	18.6±9.01
10f	c-Hexyl	2-CF3	9.12±4.44	2.00±0.80	>25
10g	Bn	3,5-Me	2.75±1.92	9.15±0.28	6.23±1.62
10h	Bn	4-NMe2	0.375±0.162	0.218±0.122	0.285±0.064
10i	t-Bu	3,5-Me	4.93±2.60	4.84±2.78	5.47±0.86
10j	t-Bu	4-NMe2	2.47±0.74	1.46±0.77	1.74±0.26
10k	t-Bu	2-F	22.2±3.8	15.7±6.87	19.0±4.58
10l	t-Bu	2-Me	23.9±1.54	13.6±8.19	23.9±1.49
10m	t-Bu	2-OMe	>25	18.4±9.34	24.5±0.75
10n	t-Bu	2-CF3	>25	18.6±9.05	>25
10o	t-Bu	2-Cl	22.9±2.64	12.8±8.66	21.6±3.37
10p	t-Bu	2-iPr	>25	12.2±9.36	>25
Vorinostat	-	-	0.299±0.045	0.22±0.05	0.470±0.023
Ricolinostat		-	2.04±0.39	1.54±0.16	2.42±0.18
HPOB	-	-	13.9±3.89	11.3±7.2	16.1±2.52