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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Kidney Int. 2022 Sep 13;102(6):1291–1304. doi: 10.1016/j.kint.2022.08.026

Figure 7. Increased select macrophage subsets in human DKD.

Figure 7.

(A) Representative immunofluorescence images of TREM2, MRC1, and S100A4 in biopsy samples of DKD and minimal change disease (MCD) (n=6 DKD and 6 MCD samples). Macrophages are co-immunostained with CD68 and DNA is counterstained with DAPI. Arrows indicate double positive staining macrophages. Arrows show examples of double-positive stained macrophages. Dotted line circle glomerulus boundaries. Scale bars, 50μM. (B) Quantification of immunostaining for MRC1, TREM2, or S100A4 per field (n=6 samples per group, 5–8 fields scored per sample). ***P <0.001 between groups by Welch’s t-test.