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. 2022 Nov 24;12:20244. doi: 10.1038/s41598-022-24496-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Stratification analysis of the RNF213 p.R4810K mutation to assess the effect of R. gnavus on MMD and ICAD. (a) To minimize the effect of the p.R4810K mutation in RNF213 gene, wildtype-specific analysis was performed. R. gnavus showed the third lowest p value as shown in the volcano plot. (b) There was no significant difference between RNF213 mutant and wildtype in the abundance of R. gnavus in patients with MMD (P = 0.39). Bars and whiskers indicate means and standard deviations. (c) In patients with ICAD, those having the p.R4810K mutation showed a trend for higher relative abundance of R. gnavus than those without the mutation, but it was not statistically significant (P = 0.098).