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. 2022 Nov 24;12:20244. doi: 10.1038/s41598-022-24496-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relative abundance analysis of gut microbiota according to the p.R4810K mutation. (a) Relative abundances of gut microbiota were compared between MMD patients with the p.R4810K mutation and those without it. Eubacterium ventriosum (E. ventriosum) showed the lowest p value, followed by Parabacteroides merdae (P. merdae), Clostridium, Flavonifractor plautii, and Dorea longicatena. (b-c) Relative abundance of E. ventriosum (b) and that of P. merdae (c) was compared among MMD patients with the p.R4810K mutation (homozygotes and heterozygotes), MMD patients without the mutation, and control individuals (without the mutation). In either analysis, there was no significant difference between patients with the p.R4810K mutation and control individuals. Bars and whiskers indicate means and standard deviations.