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. 2022 Nov 24;12:20247. doi: 10.1038/s41598-022-24292-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pairwise visual discrimination performance of icv. STZ-injected (‘STZ’) and vehicle-treated (‘control’) old rats in a touchscreen apparatus in the post-injection period of Week 12–14. Means ± SEM values are shown. (A) Percentage of correct responses (B) Number of incorrect responses. + + : p = 0.005 significant treatment effect (F(1,18) = 10.28). (C) Number of correct responses. (D) Number of completed trials. + : p = 0.018 significant treatment effect (F(1,18) = 6.83). Group size of old STZ-treated rats: n = 8.