Table 2.

Open field results of icv. STZ-injected (‘STZ’) and vehicle-treated (‘control’) rats.

Test	Old rats				Young rats
	Control		STZ		Control		STZ
	Mean	± SEM	Mean	± SEM	Mean	± SEM	Mean	± SEM
Ambulation time	188.4	± 23.23	268.5*	± 23.62	332.6	± 13.67	409.2**	± 20.48
Local movement time	727.9	± 34.40	871.3*	± 38.34	645.6	± 15.43	758.5***	± 23.12
Immobility time	833.4	± 55.32	617.8*	± 49.67	670.1	± 24.79	541.4**	± 34.13

Columns include means ± SEM values. ‘Old rats’ column: *: p < 0.05 significant difference between groups, unpaired t-test, ambulation time: t(18) = −2.32, effect size: 1.12, local movement time: t(18) = −2.72, effect size: 1.31, immobility time: t(18) = 2.72, effect size: −1.31. ‘Young rats’ column: **, ***: p < 0.01, p < 0.001 significant difference between groups; unpaired t-test, ambulation time: t(22) = −3.11, effect size: 1.33, local movement time: t(22) = −4.05, effect size: 1.73, immobility time: t(22) = 3.05, effect size: −1.30. Group size of old STZ-treated rats: n = 8.