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. 2022 Nov 25;7:382. doi: 10.1038/s41392-022-01230-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — hCD147 mice with SARS-CoV-2 infection showed fibrotic characteristics revealed by RNA-seq analysis. a KEGG enrichment analysis of pathways enriched in differentially expressed genes in three profiles showing increasing trends. b Heatmap of significantly enriched genes involved in cytokine-cytokine receptor interaction and ECM remodeling in the three profiles. c Heatmap of significantly enriched genes involved in TGF-β pathway. d Immunofluorescence staining and quantification of TGF-β in lung tissue sections from SARS-CoV-2-infected hCD147 mice and bleomycin-induced pulmonary fibrosis model at indicated time points. The rabbit IgG isotype control was used along with the staining of TGF-β. Scale bars, 50 μm. n = 12 images for each group, one-way ANOVA followed by multiple comparisons