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. 2022 Nov 24;12:20260. doi: 10.1038/s41598-022-24401-4

Figure 5.

Figure 5

(A) Bulk placental RNA-sequencing suggests prenatal THC exposure is associated with a clear gene expression signature. RNA-sequencing of rhesus macaque placental tissue at gestational day 155. Heatmap of hierarchical clustering analysis of differentially expressed genes of control (left, n = 5) and THC-exposed (right, n = 5) placental samples. (B) RNA seq pathway analysis. Top significant terms in the Gene Ontology (GO) enrichment analysis of control versus THC-exposed placentas suggest prenatal THC exposure is associated with dysregulated placental vascular development and intracellular signaling, involved in angiogenesis.