Table 1.

Doppler and contrast-enhanced ultrasound measurements by gestational age timepoint.

Variable	Group	60 days	85 days	110 days	135 days	155 days
Biparietal diameter (cm)	Control	1.93 ± 0.14	2.87 ± 0.22	3.86 ± 0.24	4.52 ± 0.26	4.80 ± 0.07
	THC	1.87 ± 0.13	3.03 ± 0.19	3.90 ± 0.22	4.37 ± 0.30	4.72 ± 0.17
Head circumference (cm)	Control	7.15 ± 0.27	10.67 ± 0.85	14.46 ± 0.87	16.88 ± 0.76	18.00 ± 0.46
	THC	6.81 ± 0.36	11.01 ± 0.54	14.70 ± 0.64	16.69 ± 0.75	17.56 ± 0.64
Abdominal circumference (cm)	Control	5.61 ± 0.42	8.87 ± 0.80	11.85 ± 0.39	13.54 ± 1.16	15.06 ± 0.51
	THC	5.56 ± 0.66	8.94 ± 0.51	11.65 ± 0.62	12.91 ± 0.71	14.13 ± 1.04
Femur length (cm)	Control	0.80 ± 0.11	1.81 ± 0.27	2.85 ± 0.26	3.44 ± 0.27	3.84 ± 0.11
	THC	0.68 ± 0.13	1.81 ± 0.25	2.72 ± 0.19	3.40 ± 0.07	3.72 ± 0.29
Placental volume blood flow (cQUV/kg)	Control	0.22 ± 0.12	0.80 ± 0.35	1.47 ± 0.64	2.19 ± 0.47	2.17 ± 0.70
	THC	0.11 ± 0.04	0.79 ± 0.22	1.38 ± 0.42	1.98 ± 0.42	2.14 ± 0.90
Uterine artery blood flow (cQuta/kg)	Control	0.14 ± 0.04	0.10 ± 0.01	0.12 ± 0.04	0.12 ± 0.04	0.12 ± 0.06
	THC	0.07 ± 0.05	0.16 ± 0.12	0.18 ± 0.07	0.17 ± 0.11	0.11 ± 0.10
Contrast enhanced ultrasound (ms−1)	Control	0.19 ± 0.04	0.22 ± 0.04	0.21 ± 0.05	0.25 ± 0.11	0.22 ± 0.08
	THC	0.23 ± 0.03	0.23 ± 0.03	0.21 ± 0.02	0.19 ± 0.06	0.21 ± 0.03
Umbilical artery pulsatility index (PI)	Control	2.70 ± 0.46	2.09 ± 0.28	1.69 ± 0.16	1.39 ± 0.31	1.09 ± 0.17
	THC	2.41 ± 0.43	1.78 ± 0.24	1.64 ± 0.41	1.32 ± 0.34	1.30 ± 0.50

CSA (cross section of uterine artery) = π(diameter/2)².

Vmean (mean velocity) = 0.5 × maximum umbilical vein velocity.

cQuta (uterine artery blood flow) = VTI × CSA × HR adjusted for maternal weight.

cQuv (placental volume blood flow) = Vmean × CSA × 60.

BPD biparietal diameter, AC abdominal circumference, FL femur length, PI pulsatility index, VTI  velocity time integral.