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. 2022 Sep 26;59(12):1196–1205. doi: 10.1136/jmg-2022-108806

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Observed and predicted 5-year breast cancer (BC) by menopausal status, using (A) the subcohort of participants with polygenic risk score (PRS) information under the model considering family history, questionnaire-based risk factors and PRS and the model considering family history, questionnaire-based risk factors, PRS and mammographic density in BI-RADS and (B) the subcohort of participants with PRS and pathogenic variant status under the model considering family history, questionnaire-based risk factors, PRS, mammographic density in BI-RADS and pathogenic variant status in the eight major BC susceptibility genes: BRCA1, BRCA2, PALB2, CHECK2, ATM, RAD51C, RAD51D and BARD1. Women were grouped into deciles of predicted risks.