Table 1.
Clinical characteristics of patients with methicillin-resistant Staphylococcus aureus bacteremia according to vancomycin treatment outcomes.
| Characteristic | Total patients (N = 118) | Vancomycin treatment outcome |
P value | |
|---|---|---|---|---|
| Success (n = 57) | Failure (n = 61) | |||
| Age ≥65 y* | 61 (51.7) | 26 (45.6) | 35 (57.4) | 0.201 |
| Male sex* | 73 (61.9) | 35 (60.3) | 38 (63.3) | 0.921 |
| Body mass index† | 23.66 (4.09) | 24.20 (4.29) | 23.16 (3.8) | 0.167 |
| Charlson's weighted index of comorbidity† | 2.61 (2.32) | 2.04 (1.71) | 3.15 (2.68) | 0.008 |
| Underlying conditions* | ||||
| Diabetes | 41 (34.7) | 21 (36.8) | 20 (32.8) | 0.644 |
| Cardiovascular disease | 31 (26.3) | 12 (21.1) | 19 (31.1) | 0.213 |
| Chronic liver disease | 12 (10.2) | 6 (10.5) | 6 (9.8) | 0.901 |
| Chronic lung disease | 11 (9.3) | 4 (7.0) | 7 (11.5) | 0.405 |
| Cerebrovascular disease | 25 (21.2) | 9 (15.8) | 16 (26.2) | 0.165 |
| Chronic kidney disease stage 3 to 5 | 7 (5.2) | 3 (5.3) | 4 (6.6) | 1.000 |
| Rheumatic disease | 10 (8.5) | 4 (7.0) | 6 (9.8) | 0.744 |
| Solid organ tumor | 24 (20.3) | 6 (10.5) | 18 (29.5) | 0.010 |
| Hematologic malignancy | 6 (5.1) | 4 (7.0) | 2 (3.3) | 0.428 |
| Immunosuppressive agents | 14 (11.9) | 5 (8.8) | 9 (14.8) | 0.315 |
| Source of infection* | 0.486 | |||
| Catheter-related bloodstream infection | 33 (28.0) | 21 (36.8) | 12 (19.7) | 0.038 |
| Bone and joint infection | 28 (23.7) | 12 (21.1) | 16 (26.2) | 0.509 |
| Skin and soft tissue infection | 21 (17.2) | 10 (17.5) | 11 (18.0) | 0.945 |
| Infective endocarditis | 5 (4.2) | 1 (1.8) | 4 (6.6) | 0.366 |
| Central nervous system infection | 1 (0.8) | 0 (0.0) | 1 (1.6) | 1.000 |
| Pneumonia | 10 (8.5) | 5 (8.8) | 5 (8.2) | 1.000 |
| Primary sepsis | 10 (8.5) | 4 (7.0) | 6 (9.8) | 0.744 |
| Other | 10 (8.5) | 4 (7.0) | 6 (9.8) | 0.744 |
| Septic shock* | 63 (53.4) | 25 (43.9) | 38 (62.3) | 0.045 |
| Pitt bacteremia score† | 2.31 (2.26) | 1.72 (1.81) | 2.87 (2.51) | 0.005 |
| Complicated infection* | 64 (54.2) | 11 (19.3) | 53 (86.9) | < 0.001 |
| Area under the concentration-time curve,† mg· hr/L | 581.50 (220.78) | 557.57 (188.50) | 603.86 (246.65) | 0.253 |
| Trough concentration,† mg/L | 15.49 (7.51) | 15.20 (6.52) | 15.76 (8.37) | 0.682 |
| Area under the concentration-time curve cut-off <373.5 mg· hr/L* | 15 (12.7) | 5 (8.8) | 10(16.4) | 0.273 |
| Bacteremia duration,† d | 5.61 (6.14) | 1.84 (2.04) | 9.13 (6.60) | < 0.001 |
| Mean time of blood culture follow-up,† d | 3.21 (1.99) | 3.02 (1.25) | 3.41 (1.13) | 0.076 |
| Development of acute kidney injury* | 42 (35.6) | 15 (26.3) | 27 (44.3) | 0.042 |
⁎
Values are presented as n (%).
†
Values are presented as mean (SD).