Table 2.
Clinical characteristics of patients with methicillin-resistant Staphylococcus aureus bacteremia according to vancomycin-induced nephrotoxicity.
| Characteristic | Total patients (N = 118) | >Nephrotoxicity |
P value | |
|---|---|---|---|---|
| No (n = 76) | Yes (n = 42) | |||
| Age ≥65 y* | 61 (51.7) | 34 (44.7) | 27 (64.3) | 0.042 |
| Male sex* | 73 (61.9) | 47 (61.8) | 26 (61.9) | 0.995 |
| Body mass index† | 23.66 (4.09) | 23.83 (4.09) | 23.37 (4.13) | 0.559 |
| Charlson's weighted index of comorbidity† | 2.61 (2.32) | 2.26 (2.05) | 3.24 (2.66) | 0.028 |
| Underlying conditions* | ||||
| Diabetes | 41 (34.7) | 25 (32.9) | 16 (38.1) | 0.570 |
| Cardiovascular disease | 31 (26.3) | 16 (21.1) | 15 (35.7) | 0.083 |
| Chronic liver disease | 12 (10.2) | 5 (6.6) | 7 (16.7) | 0.080 |
| Chronic lung disease | 11 (9.3) | 8 (10.5) | 3 (7.1) | 0.744 |
| Cerebrovascular disease | 25 (21.2) | 14 (18.4) | 11 (26.2) | 0.323 |
| Chronic kidney disease 3 to 5 | 7 (5.2) | 1 (1.3) | 6 (14.3) | 0.008 |
| Rheumatic disease | 10 (8.5) | 6 (7.9) | 4 (9.5) | 0.742 |
| Solid organ tumor | 24 (20.3) | 12 (15.8) | 12 (28.6) | 0.099 |
| Hematologic malignancy | 6 (5.1) | 5 (6.6) | 1 (2.4) | 0.420 |
| Any use of immunosuppressive agents | 14 (11.9) | 8 (10.5) | 6 (14.3) | 0.563 |
| Source of infection* | ||||
| Catheter-related bloodstream infection | 33 (28.0) | 24 (31.6) | 9 (21.4) | 0.240 |
| Bone and joint infection | 28 (23.7) | 25 (32.9) | 3 (7.1) | 0.002 |
| Skin and soft tissue infection | 21 (17.2) | 12 (15.8) | 9 (21.4) | 0.443 |
| Infective endocarditis | 5 (4.2) | 0 (0.0) | 5 (11.9) | 0.005 |
| Central nervous system infection | 1 (0.8) | 0 (0.0) | 1 (2.4) | 0.356 |
| Pneumonia | 10 (8.5) | 5 (6.6) | 5 (11.9) | 0.325 |
| Primary sepsis | 10 (8.5) | 5 (6.6) | 5 (11.9) | 0.325 |
| Other focus | 10 (8.5) | 5 (6.6) | 5 (11.9) | 0.325 |
| Septic shock* | 63 (53.4) | 37 (48.7) | 26 (61.9) | 0.168 |
| Pitt bacteremia score† | 2.31 (2.26) | 1.91 (1.77) | 3.05 (2.84) | 0.021 |
| Complicated infection* | 64 (54.2) | 35(46.1) | 29 (69.0) | 0.016 |
| Area under the concentration-time curve,† mg· hr/L | 581.50 (220.78) | 561.82 (160.85) | 698.52 (264.56) | < 0.001 |
| Trough concentration,† mg/L | 15.49 (7.51) | 13.56 (5.75) | 18.99 (8.99) | 0.001 |
| Bacteremia duration,† d | 5.61 (6.14) | 4.97 (6.01) | 6.76 (6.29) | 0.137 |
| Mean time of blood culture follow-up,† d | 3.21 (1.99) | 3.13 (1.19) | 3.38 (1.21) | 0.281 |
| Concomitant use of nephrotoxic agent* | 98 (83.1) | 57 (75.0) | 41 (97.6) | 0.002 |
⁎
Values are presented as n (%).
†
Values are presented as mean (SD).