Table 3.
Risk factors for vancomycin treatment failure and 100-day mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia determined by multivariate logistic regression analyses.
| Characteristic | Vancomycin treatment failure odds ratio |
100-d mortality outcome odds ratio |
||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis |
Multivariate analysis |
Univariate analysis |
Multivariate analysis |
|||||
| Odds ratio (95% CI) | P value | Adjusted odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | Adjusted odds ratio (95% CI) | P value | |
| Age ≥65 y | 1.61 (0.78–3.32) | 0.202 | 2.06 (0.83–5.10) | 0.118 | ||||
| Female sex | 0.96 (0.46–2.03) | 0.921 | 1.02 (0.42–2.49) | 0.969 | ||||
| Body mass index | 0.94 (0.86–1.03) | 0.168 | 0.82 (0.70–0.96) | 0.012 | 0.89 (0.80–1.00) | 0.053 | 0.84 (0.70–0.99) | 0.04 |
| Underlying conditions | ||||||||
| Diabetes | 0.84 (0.39–1.79) | 0.644 | 2.29 (0.94–5.55) | 0.068 | 6.61 (1.53–28.49) | 0.011 | ||
| Cardiovascular disease | 1.70 (0.74–3.91) | 0.215 | 1.68 (0.66–4.31) | 0.277 | ||||
| Chronic liver disease | 0.93 (0.28–3.06) | 0.901 | 1.91 (0.53–6.93) | 0.325 | ||||
| Chronic lung disease | 1.70 (0.48–6.21) | 0.41 | 0.77 (0.16–3.80) | 0.747 | ||||
| Cerebrovascular disease | 1.90 (0.76–4.72) | 0.169 | 6.05 (1.17–31.23) | 0.032 | 1.15 (0.41–3.27) | 0.789 | ||
| Chronic kidney disease stage 3 to 5 | 1.26 (0.27–5.91) | 0.767 | 2.87 (0.60–13.73) | 0.187 | ||||
| Rheumatic disease | 1.45 (0.39–5.41) | 0.584 | 4.14 (1.10–15.63) | 0.036 | 12.35 (1.70–89.83) | 0.013 | ||
| Solid organ tumor | 3.56 (1.30–9.76) | 0.014 | 6.61 (1.19–36.81) | 0.031 | 5.71 (2.14–15.24) | < 0.001 | 17.29 (3.02–98.98) | 0.001 |
| Hematologic malignancy | 0.45 (0.08–2.55) | 0.367 | 0.70 (0.08–6.24) | 0.746 | ||||
| Immunosuppressive agents | 1.80 (0.57–5.74) | 0.32 | 4.47 (1.40–14.27) | 0.011 | ||||
| Septic shock | 2.12(1.01–4.42) | 0.046 | 3.80 (1.40–10.33) | 0.009 | ||||
| Pitt bacteremia score | 1.25 (1.04–1.50) | 0.018 | 1.32 (0.98–1.78) | 0.072 | 1.44 (1.16–1.79) | 0.001 | 1.51 (1.09–2.09) | 0.012 |
| Complicated infection | 27.71 (10.27–74.76) | < 0.001 | 77.56 (16.74–359.37) | < 0.001 | 4.79 (1.66–13.78) | 0.004 | 5.03 (1.16–21.85) | 0.031 |
| Development of acute kidney injury | 2.22 (1.02–4.83) | 0.044 | 8.14 (3.04–21.84) | < 0.001 | 6.74 (1.82–24.99) | 0.004 | ||
| Area under the concentration-time curve cut-off <373.5 mg· hr/L | 2.04 (0.65–6.38) | 0.221 | 0.87 (0.23-3.35) | 0.839 | ||||