Table 2.
CMR derived LV function.
| Variable | HFpEF n = 34 |
NCD n = 34 |
Mean difference (95% CI) | Significance p |
|---|---|---|---|---|
| Cardiovascular magnetic resonance volumetry | ||||
| LV EDV | 68.3 (60.7, 77.3) | 68.5 (57.4, 76.8) | −0.8 (−8.1, 6.5) | 0.741 |
| LV ESV | 19.6 (14.8, 25.9) | 20.4 (14.8, 24.3) | 0.5 (−3.2, 4.1) | 0.917 |
| LV SV | 49.6 (42.1, 54.5) | 46.7 (40.1, 53.0) | −1.3 (−6.2, 3.7) | 0.447 |
| LV EF | 69.0 (66.3, 76.1) | 69.0 (65.0, 75.6) | −0.6 (−4.0, 2.8) | 0.731 |
| LV Mass | 57.0 (51.0, 66.9) | 55.6 (50.4, 72.0) | 1.7 (−4.4, 7.8) | 0.932 |
| Cardiovascular magnetic resonance deformation imaging | ||||
| FT LV GLS | −19.9 (−18.8, −22.5) | −21.0 (−19.0, −23.2) | −0.8 (−2.3, 0.7) | 0.194 |
| FT LV GCS | −35.2 (−30.9, −39.0) | −34.9 (−30.7, −36.9) | 0.0 (−11.0, 10.9) | 0.516 |
| FT LV GRS | 66.2 (57.7, 74.2) | 63.4 (56.5, 70.1) | −5.7 (−14.1, 2.7) | 0.275 |
| LV LAS rest | 13.5 (11.4, 15.4) | 13.9 (12.0, 15.9) | 0.7 (−0.6, 2.1) | 0.542 |
| LV LAS exercise-stress | 14.9 (12.5, 18.0) | 18.9 (15.7, 21.7) | 4.0 (2.1, 6.0) | <0.001 |
| Cardiovascular magnetic resonance hemodynamic force | ||||
| LV longitudinal force (RMS) | 15.8 (13.4, 19.6) | 18.3 (14.8, 27.3) | 5.5 (1.6, 9.4) | 0.035 |
| Systolic peak | 38.6 (29.3, 50.5) | 52.4 (38.5, 67.4) | 18.6 (8.2, 29.0) | 0.002 |
| Systolic impulse | 20.8 (14.4, 27.5) | 25.3 (20.0, 39.1) | 9.0 (3.8, 14.3) | 0.006 |
| LV systolic/diastolic transition | −10.6 (−7.3, −14.6) | −10.9 (−7.3, −14.3) | −0.5 (−3.7, 2.7) | 0.961 |
| Diastolic deceleration | 9.1 (7.1, 11.3) | 7.1 (6.0, 9.0) | −1.0 (−3.3, 1.2) | 0.044 |
| Atrial thrust | −3.8 (−2.1, −6.3) | −5.4 (−3.7, −7.7) | −1.8 (−4.6, 1.0) | 0.029 |
| Diastolic deceleration/atrial thrust | 1.9 (1.2, 3.3) | 1.3 (0.7, 1.9) | 2.3 (−4.0, 8.7) | 0.018 |
NCD, non-cardiac dyspnoea; LV, left ventricular; EDV, end-diastolic volumel; ESV, end-systolic volume; SV, stroke volume; EF, ejection fraction; FT, feature-tracking; GLS/GCS/GRS, global longitudinal/circumferential/radial strain; LAS, long axis strain; RMS, root mean square; HDF, hemodynamic force. Volumes are given in ml/m2 body surface area (BSA), mass in g/m2 BSA, strain and HDF values in %. Independent continuous parameters are presented as medians with interquartile ranges and were compared by using the Mann–Whitney U test (asymptotic). Bold p-values indicate statistical significance. ∗conventional CMR cardiac function parameters adapted fromRef. 10