Table 2.

Impact of TMTV, ECOG-PS, IPI, and combined TMTV/ECOG-PS for survival (PFS and OS) in the PETAL, GOYA, and RW series

Variables and index	PETAL, HR (95% CI), P value		GOYA, HR (95% CI), P value		RW, HR (95% CI), P value
	PFS	OS	PFS	OS	PFS	OS
ECOG-PS ≥2	1.94 (1.30-3.00), .006	2.46 (1.50-4.00), <.001	1.75 (1.37-2.22), <.001	1.95 (1.47-259), <0.001	2.18 (1.50-3.10), <.001	2.61 (1.80-3.80), <.001
TMTV >220 cm3	2.88 (2.10-4.00), <.001	2.69 (1.80-4.00), <.001	1.75 (1.43-2.14), <.001	1.84 (1.42-2.38), <.001	2.73 (1.90-3.80), <.001	2.80 (1.90-4.10), <.001
IPI 3-5	2.33 (1.70-3.20), <.001	2.41 (1.70-3.50), <.001	1.81 (1.50-2.2), <.001	2.1 (1.70-2.60), <.001	2.42 (1.70-3.50), <.001	3.23 (2.10-5.00), <.001
Combined TMTV/ECOG-PS∗
1 risk factor	2.92 (2.00-4.20), <.001	2.71 (1.80-4.20), <.001	1.47 (1.18-1.82), .00493	1.46 (1.11-1.92), .00683	2.37 (1.60-3.50), <.001	2.24 (1.40-3.50), <.001
2 risk factors	3.32 (2.00-5.50), <.001	3.85 (2.20-6.80), <.001	2.85 (2.11-3.84), <.001	3.35 (2.34-4.78), <.001	3.85 (2.50-5.90), <.001	4.61 (2.90-7.30), <.001

CI, confidence interval; HR, hazard ratio.

^∗Risk factors are TMTV >220 cm³ and ECOG-PS ≥2.