Table 4.
Comparison of the combined TMTV/ECOG-PS with IPI in high-risk patients
| Indexes | PETAL |
GOYA |
RW |
|||
|---|---|---|---|---|---|---|
| PFS | OS | PFS | OS | PFS | OS | |
| All patients (N = 2174) | ||||||
| NRI (±SE) | +0.21 (0.09) | +0.24 (0.10) | +0.24 (0.07) | +0.15 (0.056) | 0.00 (0.10) | −0.17 (0.11) |
| NRIe/NRIne, % | −35.1/+56.5 | −31.5/+55.0 | −9.9/+12.3 | +8.9/+6.5 | −28.8/+29.1 | −0.8/−16.1 |
| C-index (difference vs IPI) | 0.655 (+0.046) | 0.658 (+0.039) | 0.6065 (-0.0379) | 0.6237 (−0.0367) | 0.643 (+0.048) | 0.666 (+0.043) |
| <60 y (n = 884) | ||||||
| NRI (±SE) | +0.54 (0.15) | +0.66 (0.19) | +0.041 (0.08) | +0.14 (0.06) | +0.48 (0.20) | +0.06 (0.23) |
| NRIe/NRIne, % | +5.1/+48.5 | +22.6/+43.1 | +1.1/+3.1 | +20.3/−5.9 | −11.8/+60.0 | +21.7/−15.5 |
| C-index (difference vs IPI) | 0.687 (+0.091) | 0.695 (+ 0.096) | 0.6199 (−0.0387) | 0.6495 (−0.0327) | 0.600 (+0.022) | 0.619 (+0.008) |
| >60 y (n = 1293) | ||||||
| NRI (±SE) | +0.54 (0.12) | +0.55 (0.13) | +0.07 (0.07) | +0.13 (0.07) | +0.03 (0.13) | +0.01 (0.13) |
| NRIe/NRIne, % | +6.4/+48.1 | +10.5/+44.8 | +14.3/−7.0 | +12.3/+1.1 | −22.4/+25.0 | −4.4/+5.4 |
| C-index (difference vs IPI) | 0.633 (+0.030) | 0.640 (+ 0.045) | 0.5994 (−0.0457) | 0.6074 (−0.0521) | 0.654 (+0.068) | 0.665 (+0.068) |
NRIe, event NRI; NRIne, nonevent NRI; SE, standard error.