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. 2022 Nov 11;14:1040293. doi: 10.3389/fnagi.2022.1040293

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Copyright © 2022 Zhou, Zhou, Xiang, Zhao, Pan, Wu, Xu, Chen, Sun, Wu, Zhu, Wu, Li, Yan, Guo, Tang, Lei and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of the three subtypes at baseline. The figure was depicted according to the mean values or percentages of subtypes. The red color represented a more severe deficit and the blue color referred to a less severe symptom. The darker the figure described, the larger difference were shown among the subtypes. Variables with P value <0.05 are shown. LEDD, Levodopa Equivalent Daily Dose; UPDRS, Unified Parkinson’s disease Rating Scale; H&Y, Hoehn and Yahr; FOG, freezing of gait; NMSS, Non-Motor Symptoms Scale; PDSS, Parkinson’s Disease Sleep Scale; SCOPA-AUT, the Scale for Outcomes in Parkinson’s Disease for Autonomic Dysfunction; PDQ-39, Parkinson’s disease questionnaire-39 item version; RBD, Rapid Eye Movement Sleep Behavior Disorder; EDS, excessive daytime sleepiness.