Table 5.
Result of Correlation Network Analysis among relative frequency of gut microbes, phenotype factors, and characteristic metabolites.
| Gut microbes | Phenotype factors | Correlation coefficient and P-value | Characteristic metabolites | Correlation coefficient and P-value |
|---|---|---|---|---|
| HFD | ||||
| Clostridium | Body weight | r = 0.94, P = 0.005 | Tetrahydrocorticosterone | r = 0.89, P = 0.019 |
| NWLD | ||||
| Butyricicoccus | ||||
| TG | r = −0.94, P = 0.0048 | L-aspartic acid | r = −0.94, P = 0.0048 | |
| VF% | r = −0.83, P = 0.0416 | L-glutamate | r = −0.83, P = 0.0416 | |
| hs-CRP | r = −0.89, P = 0.0188 | |||
| Desulfovibrio | ||||
| TG | r = −0.94, P = 0.048 | L-asparaguses | r = −0.94, P = 0.0048 | |
| VF% | r = −0.83, P = 0.0416 | |||
| BF% | r = 0.81, P = 0.0499 | |||
| Erythrobacter | ||||
| hs-CRP | r = −0.88, P = 0.0206 | |||
| BF% | r = 0.95, P =0.003 | |||
| Ruminococcus | ||||
| TG | r = −0.83, P = 0.0416 | |||
| VF% | r = −0.94, P = 0.0048 | |||
| Gemmiger | ||||
| hs-CRP | r = −0.81, P = 0.0499 | |||
| Anaerotruncus | ||||
| BF% | r = 0.84, P = 0.0361 |
P-value < 0.05 were listed. NC, normal control group; HFD, high-fat diet group (model); NWLD, novel weight loss diet group; TG, total cholesterol; hs-CRP, high-sensitivity C-reactive protein; VF%, visceral fat percentage; BF%, brown fat percentage.