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. 2022 Nov 11;16:951204. doi: 10.3389/fnhum.2022.951204

TABLE 3.

Alcohol and other substance use characteristics.

Extended cannabis use group

Full sample (n = 158) Minimal/no cannabis exposure (n = 53) Moderate cannabis exposure (n = 52) Heavy cannabis exposure (n = 53) Group comparison





M SD M SD M SD M SD F p
Cumulative alcohol exposure 86.01 176.18 24.76(3) 65.76 68.57(3) 100.76 1485.23(1,2) 262.65 9.5 <0.001**

N % N % N % N % χ 2 p

Daily tobacco smoker (age 20) 44 27.8 3(2,3) 5.7 14(1,3) 26.9 27(1,2) 50.9 25.76 <0.001**
Daily tobacco smoker (age 22) 46 29.1 3(2,3) 5.7 13(1,3) 25 30(1,2) 56.6 33.96 <0.001**
Lifetime history of illicit substance use
Cocaine/crack 16 10.1 0(2,3) 0 4(1,3) 7.7 12(1,2) 22.6 15.43 <0.001**
Stimulants 13 8.2 1 1.9 5 9.6 7 13.2 4.7 0.096
Sedatives 20 12.7 1(3) 1.9 5(3) 9.6 14(1,2) 26.4 15.07 0.001**
Opioids 21 13.3 1(3) 1.9 5(3) 9.6 15(1,2) 28.3 16.95 <0.001**
Inhalants 5 3.2 0 0 1 1.9 4 7.5 5.32 0.07
Hallucinogens 19 12 0(2,3) 0 7(1) 13.5 12(1) 22.6 12.99 0.002**
Ecstasy 22 13.9 0(2,3) 0 5(1,3) 9.6 17(1,2) 32.1 23.95 <0.001**

*p < 0.05; **p < 0.01. Superscript numbers in parentheses indicate which groups were significantly different from one another, based on pairwise Bonferroni-corrected post hoc testing or pairwise χ2 tests, as applicable (1 = minimal/no cannabis exposure group, 2 = moderate cannabis exposure group, 3 = heavy cannabis exposure group). Cumulative alcohol exposure reflects the sum of participants’ annual quantity of alcohol use (average days/month and average drinks/occasion were multiplied in order to obtain a measure of overall quantity of alcohol exposure for each year). Lifetime history of illicit substance use was assessed using the Lifetime History of Drug Use and Drug Consumption (LHDU) semi-structured interview; positive lifetime history was determined based by consensus from age 20 and age 22 study visits.