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Supplement Table 1. List the reason for withdrawal.

Patient No. Group Comment
S02D02 Placebo Protocol compliance becomes impossible due to a newly emergent disease or symptom or worsening of clinical laboratory test findings. (Diuretic IV injection received before withdrawal)
S17L05 Tolvaptan Compliance with the study protocol becomes impossible or the investigator judge withdrawal to be necessary. (Adverse Event: Pneumonia)
S20L07 Placebo Compliance with the study protocol becomes impossible or the investigator judge withdrawal to be necessary. (Non-compliance the standard control during the treatment period)
S03F03 Tolvaptan Protocol compliance becomes impossible due to a newly emergent disease or symptom or worsening of clinical laboratory test findings. (Serious Adverse Event: Ischaemic Hepatitis)
S02N02 Placebo A major deviation is discovered.
S04K04 Placebo The patient requested to withdraw from the study.