Supplement Table 1. List the reason for withdrawal.
Patient No. | Group | Comment |
S02D02 | Placebo | Protocol compliance becomes impossible due to a newly emergent disease or symptom or worsening of clinical laboratory test findings. (Diuretic IV injection received before withdrawal) |
S17L05 | Tolvaptan | Compliance with the study protocol becomes impossible or the investigator judge withdrawal to be necessary. (Adverse Event: Pneumonia) |
S20L07 | Placebo | Compliance with the study protocol becomes impossible or the investigator judge withdrawal to be necessary. (Non-compliance the standard control during the treatment period) |
S03F03 | Tolvaptan | Protocol compliance becomes impossible due to a newly emergent disease or symptom or worsening of clinical laboratory test findings. (Serious Adverse Event: Ischaemic Hepatitis) |
S02N02 | Placebo | A major deviation is discovered. |
S04K04 | Placebo | The patient requested to withdraw from the study. |