Table 2. Follow-up outcomes of study cohort after imputation and GBM-IPTW.
| Outcome | Event rate (%) | HR or SHR (95% CI) | ||||
| Fixed 5/10 | Fixed 5/20 | Free 5/10 | Fixed 5/20 vs. Fixed 5/10 | Free 5/10 vs. Fixed 5/10 | Free 5/10 vs. Fixed 5/20 | |
| Cardiovascular outcome | ||||||
| Coronary intervention | 0.80 | 1.2 | 0.90 | 1.51 (0.75-3.04) | 1.15 (0.53-2.50) | 0.76 (0.36-1.59) |
| Acute myocardial infarction | 0.00 | 1.8 | 0.12 | NA | NA | NA |
| Stroke | 3.8 | 3.6 | 3.6 | 0.99 (0.69-1.41) | 0.96 (0.66-1.40) | 0.97 (0.66-1.45) |
| All-cause death | 1.8 | 1.0 | 1.9 | 0.56 (0.16-1.97) | 1.06 (0.49-2.32) | 1.91 (0.54-6.80) |
| Composite cardiovascular outcome* | 6.1 | 6.3 | 6.0 | 1.10 (0.66-1.85) | 1.01 (0.64-1.60) | 0.92 (0.53-1.59) |
| Renal outcome | ||||||
| eGFR decline > 40% | 9.2 | 10.6 | 10.9 | 1.23 (0.99-1.53) | 1.23 (0.98-1.54) | 1.00 (0.79-1.25) |
| Dialysis | 1.3 | 1.3 | 1.8 | 1.03 (0.56-1.91) | 1.49 (0.83-2.66) | 1.44 (0.78-2.66) |
| Composite outcome of eGFR decline > 40% or dialysis | 9.5 | 10.8 | 11.2 | 1.22 (0.99-1.52) | 1.23 (0.98-1.53) | 1.00 (0.80-1.26) |
| Composite outcome of eGFR decline > 40% or dialysis or all-cause death | 10.4 | 11.1 | 11.5 | 1.14 (0.78-1.65) | 1.14 (0.82-1.58) | 1.01 (0.68-1.49) |
| Safety outcome | ||||||
| New-diagnosed diabetes mellitus | 11.3 | 13.2 | 8.5 | 1.43 (1.11-1.85)* | 0.82 (0.61-1.10) | 0.57 (0.42-0.77)* |
| ALT > 105 U/L | 3.9 | 3.8 | 2.1 | 1.02 (0.72-1.46) | 0.53 (0.34-0.83)* | 0.52 (0.33-0.82)* |
ALT, alanine amino transferase; CI, confidence interval; CV, cardiovascular; eGFR, estimated Glomerular filtration rate; GBM-IPTW, generalized boosted modeling-inverse probability of treatment weighting; HR, hazard ratio; NA, not applicable; SHR, subdistribution hazard ratio.
* Anyone of coronary intervention, acute myocardial infarction, stroke or all-cause death.