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Antitumor effect of DHTS on OXA-resistant CRC. DHTS can exert anti-OXA-induced CRC resistance through multiple links and targets, including blocking the cell cycle in S and G2/M phases, promoting apoptosis, inducing DNA damage, and reducing MRP1, P-gp, Bcl-2, Bcl-xL, SHP2, and β-catenin protein.
