Table 2.
Upregulated pathways for the infarct core compared to infarct border (green vs. orange), with an adjusted p-value <0.05 and ranked by the combined score 1.
| Upregulated Pathways | Overlap | Combined Score |
|---|---|---|
| RHO GTPases activate CIT | 1/16 | 1422.78 |
| RHO GTPases Activate ROCKs | 1/17 | 1318.68 |
| RHO GTPases activate PAKs | 1/21 | 1012.63 |
| Nephrin interactions | 1/22 | 955.53 |
| Sema4D induced cell migration and growth-cone collapse | 1/24 | 857.29 |
| Sema4D in semaphorin signaling | 1/27 | 740.22 |
| Smooth Muscle Contraction | 1/33 | 576.31 |
| EPHA-mediated growth cone collapse | 1/34 | 555.22 |
| Elastic fibre formation | 1/41 | 439.30 |
1 Reactome pathway analysis was conducted including the significantly altered proteins from the infarct core vs. unaffected tissue (green vs. red). Overlap indicates the number of proteins detected compared to the number of proteins in the pathway.