Table 5.
MiRs’ effective roles in OA.
| miRs with Protective Roles in OA | Effective Role | miRs with Destructive Roles in OA | Effective Role |
|---|---|---|---|
| miR-195-5p | inhibits chondrocyte apoptosis and the inflammatory response | miR-9 | - |
| miR-335-5p | significantly increases cell viability and autophagy-related factors, and reduces inflammatory mediators | miR-145 | miR-145 down-regulation increases LPS-induced inflammatory injury |
| miR-337-3p | inhibits the apoptosis of OA chondrocytes | miR-140 | - |
| miR-140-5p | inhibits inflammation mediators and cartilage degradation and upregulates chondrogenic proteins | miR-30b | promotes cartilage degradation |
| miR-146a | reduces the expression levels of inflammatory genes and catabolic proteases in nucleus pulposus | miR-23a-3p | inflammatory stimulus |
| miR-27a-5p | - | miR-483-5p | severe cartilage damage, cartilage matrix degeneration, and increased chondrocyte hypertrophy |
| miR-20 | inhibits chondrocyte proliferation and autophagy | miR-125b | promotes inflammatory injury |
| miR-103 | - | miR-26a-5p | - |
| miR-222 | induces osteoblast proliferation and attenuates cardiomyocyte hypertrophy | miR-27a | increases the proliferation, apoptosis and inflammation of chondrocytes |
| miR-26a | regulates chondrocytes apoptosis | miR-107 | inhibits cell apoptosis and promotes autophagy in OA chondrocytes |
| miR-26b | regulates chondrocytes apoptosis | miR-140-5p | increases cartilage degradation |
| miR-93-5p | attenuates chondrocyte apoptosis and cartilage degradation | miR-146a | increases and promotes inflammation |
| miR-377-3p | alleviates chondrocyte apoptosis and cartilage degradation | miR-218-5p | promotes cartilage destruction |
| miR-16 | - | miR-320c | promotes cartilage destruction |
| miR-132 | - | miR-449a | promotes chondrocytes degradation |
| miR-33b-3p | - | miR-324-5p | - |
| miR-140-3p |
protective against OA development via inhibition of inflammation
and oxidative stress, enhancement of autophagy |
miR-1236 | induces cell apoptosis in chondrocytes, suppresses cell proliferation. |
| miR-671-3p | - | miR-16-5p | - |
| miR-675-3p | inhibits apoptosis, matrix degradation and inflammation of chondrocytes. | miR-29b | facilitates chondrocyte apoptosis |
| miR-142-5p | attenuates chondrocyte apoptosis and cartilage degradation | miR-34a-5p | promotes cartilage damage |
| miR-197 | promotes chondrocyte proliferation, increases migration, and inhibits inflammation | miR-27b-3p | promotes cartilage damage |
| miR-329 | - | miR-455-3p | enhances chondrocytes apoptosis and inflammation |
| miR-655 | - | miR-98 | promotes inflammation |
| miR-708-3p | - | miR-140-3p | promotes inflammation |
| miR-934 | - | miR-24-3p | promotes inflammation |
| miR-146 | negative regulator of immune responses | miR-29c-3p | promotes inflammation |
| miR-186-5p | promotes inflammation | ||
| miR-155 | - |