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. 2022 Nov 18;14(11):2553. doi: 10.3390/v14112553

Figure 2.

Figure 2

IFITM3 inhibits SARS-CoV-2 entry. (A) Illustration of the β-lactamase-Vpr assay. (B) HEK293T-ACE2 cells were transfected with increasing amounts of GST or IFITM3 and then infected with BlaM pseudovirus particles. BlaM activity was determined by flow cytometry. (C) Summary of the percentages of cells exhibiting CCF2-AM cleavage in (B). (D) HEK293T-ACE2 cells were transfected with IFITM3 or Δ(1–21) IFITM3 DNA, and then infected with BlaM pseudovirus particles. BlaM activity was determined by flow cytometry. (E) Summary of the percentages of cells exhibiting CCF2-AM cleavage in (D). Data in the bar charts are presented as mean ± SD of three independent experiments. ns, not significant. *, p < 0.05; **, p < 0.01.