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. 2022 Nov 18;14(11):2553. doi: 10.3390/v14112553

Figure 4.

Figure 4

The rs12252 CC genotype of IFITM3 is associated with the risk of SARS-CoV-2 infection. (A) Illustration of SNPs rs12252 and rs34481144 of IFITM3. (B) Frequency of rs12252 alleles in our 203 COVID-19 patient cohort (WH patients), including 133 mild cases (65.5%), 43 severe cases (21.2%), and 27 deaths (13.3%). Han Chinese: healthy Chinese Han population (from the 1000 genome project). (C) The frequency of the CC genotype (37.9%) was increased (p = 0.04) in our COVID-19 patient cohort. (D) Frequency of the rs12252-C allele in our cohort and in the Chinese Han population (data from the 1000 genomes project). (E) Frequencies of the rs12252 alleles in mild, severe, and death cases. (F) Frequency of the CC genotype in mild, severe, and death cases. (G) Viral load in the throat swab samples from the CC and CT/TT carriers. (H,I) Viral load in the CC and CT/TT carriers from the mild group (H) and the severe group (I). WH patients, Wuhan patients; *, p < 0.05.