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. 2022 Nov 10;14(22):4752. doi: 10.3390/nu14224752

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetic interaction between RSV and alcohol. (A) Pharmacokinetic study design of RSV, alcohol and their combination in mice; (B) Typical multiple–reaction monitoring chromatograms of blank mouse blood(a), a blank mouse blood sample spiked with alcohol and IS(b), and a blood sample after the intragastric administration of alcohol (c). (C) Pharmacokinetics of alcohol in the alone and combination groups. (D)Typical multiple-reaction monitoring chromatograms of blank mouse blood(a), a blank mouse blood sample spiked with RSV, R3G, R3S, and IS(b), and a blood sample after the intragastric administration of RSV(c). (E) Pharmacokinetics of RSV and its main metabolites in the alone and combination groups. * p < 0.05; *** p < 0.001.