Table 3.
Comparison of pharmacokinetic parameters of alcohol administered alone and combined with resveratrol.
| Parameters (Unit) | Groups | |
|---|---|---|
| Alone | Combination | |
| AUC(0–12h) (nmol.h/mL) | 228.3 ± 24.6 | 427.9 ± 47.2 **↑ |
| AUC(0–∞) (nmol.h/mL) | 228.6 ± 24.6 | 516.7 ± 81.0 **↑ |
| Cmax (nmol/mL) | 49.3 ± 3.1 | 74.9 ± 6.4 **↑ |
| Tmax (h) | 1.0 ± 0.2 | 1.5 ± 0.3 |
| t1/2 (h) | 0.8 ± 0.2 | 2.9 ± 1.0 |
AUC(0–12h), area under the plasma concentration–time curve from 0 to 12 h; AUC(0–∞), area under the plasma concentration–time curve from 0 to infinity hours; Cmax, maximal concentration; Tmax, time to peak concentration; t1/2, eliminate half-life. Data are expressed as the mean ± SEM. ** p < 0.01. ↑: significantly increased.