Table 5.
Comparison of metabolizing enzyme activities for alcohol and resveratrol among the groups.
| Parameters (Unit) | Metabolic Compounds | Enzyme Activities | ||
|---|---|---|---|---|
| Vehicle | ALD Model | RSV-Alcohol | ||
| Adh (U/mg prot) | alcohol | 6.1 ± 0.3 | 3.9 ± 0.3 ***↓ | 4.8 ± 0.3 #↑ |
| Aldh (U/mg prot) | alcohol | 1.3 ± 0.1 | 2.8 ± 0.3 ***↑ | 2.1 ± 0.2 |
| Cyp2e1 (ng/mL) | alcohol | 5.9 ± 0.4 | 14.8 ± 0.6 ***↑ | 21.7 ± 0.9 ###↑ |
| Ugt1a1 (%) | RSV | 75.4 ± 16.8 | 89.0 ± 10.3 | / |
| Sult1a1 (%) | RSV | 4.8 ± 0.8 | 4.9 ± 0.8 | / |
Adh, alcohol dehydrogenase; Aldh, aldehyde dehydrogenase; Cyp2e1, cytochrome P4502e1; Ugt1a1, Uridine diphosphate glucuronic acid transferase 1a1; Sult1a1, sulfatase transferase 1a1; ALD, alcoholic liver disease; RSV-alcohol, resveratrol soaked in alcohol. Data are expressed as the mean ± SEM. /, undetected. *** p < 0.001, vs. Vehicle group. # p < 0.05; ### p < 0.001, vs. ALD group. ↑: significantly increased; ↓: significantly decreased.