Table 4.
Schematic representation of the comparison of the different variables studied, within the melatonin group, at T0 and T1. # p < 0.05 vs. Melatonin T0 group. Data are expressed as mean ± standard deviation (SD).
| Variable | Melatonin T0 | Melatonin T1 | Intergroup ANOVA (p) |
|---|---|---|---|
| TAC (CRE) | 1.41 ± 0.61 | 0.92 ± 0.39 | 0.041 |
| RHI RHI ≤ 1.67 RHI ≤ 2.00 |
1.97 ± 0.74 7 (46.7%) 8 (53.3%) |
1.54 ± 0.67 6 (60.0%) 6 (69.0%) |
0.241 0.688 1.000 |
| Aix@75 (%) | 12.40 ± 18.43 | 5.30 ± 11.09 | 0.020 |
| Aix@75 ≥ 17% | 6 (40.0%) | 2 (20.0%) | 0.402 |
| SBP (mmHg) | 135 ± 10 | 129 ± 14 | 0.401 |
| DBP (mmHg) | 86 ± 6 | 86 ± 6 | 1.000 |
| MAP (mmHg) | 104 ± 9 | 102 ± 9 | 0.779 |
| PP (mmHg) | 48 ± 10 | 42 ± 10 | 0.204 |
| HR (bpm) | 73 ± 11 | 71 ± 13 | 0.944 |
| SBPao (mmHg) | 125 ± 9 | 120 ± 14 | 0.484 |
| DBPao (mmHg) | 89 ± 11 | 87 ± 7 | 0.799 |
| PPao (mmHg) | 35 ± 8 | 33 ± 9 | 0.674 |
| APao (mmHg) | 9 ± 8 | 9 ± 5 | 1.000 |
| Aix@75 (%) | 26.57 ± 21.07 | 23.43 ± 10.73 | 0.345 |
| Aix@75 ≥ 35% | 7 (50.0%) | 0 (0.0%) | 0.022 # |
| cfPWV (m/s) | 4.60 ± 2.90 | 6.33 ± 3.20 | 0.345 |
| cfPWV > 9.6 m/s | - | - | - |
CRE: μM Copper Reducing Equivalents; RHI: reactive hyperaemia index; Aix: augmentation index; Aix@75: augmentation index corrected for 75 bpm; SBP: systolic blood pressure; DBP: diastolic blood pressure; MAP: mean arterial pressure; PP: pulse pressure; HR: heart rate; SBPao: aortic systolic blood pressure; DBPao: aortic diastolic blood pressure; PPao: aortic pulse pressure; APao: aortic augmentation pressure; cfPWV: carotid-femoral pulse wave velocity.