Table 1.
Time Point | Modified NSS | TBI-Vehicle | TBI-Carvacrol | p-Value |
---|---|---|---|---|
1 h | Motor tests | 4.0 ± 0.45 | 4.2 ± 0.37 | |
Sensory tests | 1.2 ± 0.2 | 1.6 ± 0.24 | ||
Beam balance tests | 6.0 ± 0.0 | 6.0 ± 0.0 | ||
Reflexes absent and abnormal movements | 2.4 ± 0.24 | 2.0 ± 0.0 | ||
Total points | 13.6 ± 0.4 | 13.8 ± 0.2 | 0.671 | |
24 h | Motor tests | 4.0 ± 0.2 | 3.6 ± 0.24 | |
Sensory tests | 1.0 ± 0.0 | 1.2 ± 0.2 | ||
Beam balance tests | 5.8 ± 0.2 | 6.0 ± 0.0 | ||
Reflexes absent and abnormal movements | 1.0 ± 0.32 | 1.2 ± 0.2 | ||
Total points | 11.6 ± 0.24 | 12 ± 0.32 | 0.348 | |
48 h | Motor tests | 3.4 ± 0.24 | 3.0 ± 0.0 | |
Sensory tests | 1.2 ± 0.2 | 1.0 ± 0.0 | ||
Beam balance tests | 5.4 ± 0.24 | 5.4 ± 0.4 | ||
Reflexes absent and abnormal movements | 0.8 ± 0.2 | 1.2 ± 0.2 | ||
Total points | 10.8 ± 0.2 | 10.6 ± 0.4 | 0.671 | |
72 h | Motor tests | 3.0 ± 0.32 | 2.2 ± 0.37 | |
Sensory tests | 1.0 ± 0.32 | 0.6 ± 2.4 | ||
Beam balance tests | 5.6 ± 0.24 | 3.8 ± 0.49 | ||
Reflexes absent and abnormal movements | 1.0 ± 0.0 | 1.2 ± 0.2 | ||
Total points | 10.6 ± 0.4 | 7.8 ± 0.73 | 0.015 | |
7 days | Motor tests | 2.2 ± 0.37 | 1.0 ± 0.0 | |
Sensory tests | 0.8 ± 0.2 | 0.0 ± 0.0 | ||
Beam balance tests | 3.8 ± 0.58 | 1.2 ± 0.37 | ||
Reflexes absent and abnormal movements | 1.0 ± 0.0 | 0.6 ± 0.24 | ||
Total points | 7.8 ± 0.86 | 2.8 ± 0.58 | 0.002 |
Data are expressed as the mean ± standard deviation. Higher scores represent a more severe neurological deficit. The mNSS scores were compared using the Wilcoxon rank-sum test. Abbreviations: NSS, Neurological Severity Scale.