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. 2022 Nov 10;23(22):13840. doi: 10.3390/ijms232213840

Table 2.

Effects of TRPM7 inhibition in multiple acute neurological injuries.

Disease Models Species TRPM7 Inhibitors Divalent Ions Immunohistochemistry Neurological Assessment Reference
TBI Rats Carvacrol, 2-APB Zn2+↓ TRPM7 expression↓
Degenerating neurons↓
Dendritic injury↓
Oxidative/Nitrosative stress↓
Glutathione depletion↓
M1 microglial activation↓
Neuronal death↓		 Neurological dysfunction↓
Stroke Rats Carvacrol, Zn2+↓ TRPM7 expression↓
Degenerating neurons↓
Dendritic injury↓
Oxidative stress↓
Microglial activation ↓		 N/A [35]
Epilepsy Rats Carvacrol, 2-APB Zn2+↓ TRPM7 expression↓
Degenerating neurons↓
Dendritic injury↓
Oxidative stress↓
M1 microglial activation↓
BBB disruption↓
Apoptosis↓
Neuronal death↓		 N/A [36]

Abbreviations: TBI, Traumatic Brain Injury; TRPM7, transient receptor potential melastatin 7; 2-APB, 2-Aminoethoxydiphenyl borate; BBB, Blood–Brain Barrier.