Table 3.
Articles describing POP-induced reprotoxicity and endocrine disruption.
| Molecule | Species | Consequences | Technique | Article |
|---|---|---|---|---|
| PFOA | Mus musculus cells (MLTC-1 Leydig) | Stimulation of steroidogenesis by accelerating fatty acid metabolism and steroidogenic processes. | nanoLC-MS/MS | [65] |
| Homo sapiens cells (SKBr3) | Dysregulation of the cAMP pathway by adenosine receptors. | TMT labelling and nanoLC-MS/MS | [13] | |
| Mus musculus (BALB/c) | Inhibition of proteins involved in steroidogenesis (CYP11A1, INSL3) in a dose-dependent manner. | iTRAQ labelling and LC-ESI-MS/MS | [66] | |
| PCB | Homo sapiens cells (MCF7) | Endocrine disruption properties: dysregulated proteins involved in stress response and cytoskeleton process. | 2D-DIGE and MALDI-TOF/TOF | [67] |
| Homo sapiens cells (MCF7) | Endocrine disruption properties: dysregulated proteins involved in stress response and cytoskeleton process in subcellular fractions. | 2D-DIGE and MALDI-TOF/TOF | [68] | |
| Homo sapiens cells (H295R) | Perturbation of steroidogenesis: dysregulated proteins involved in protein synthesis, cortisol synthesis, stress response, and apoptosis. | 2D-DIGE and LC-MS/MS | [69] | |
| Mus musculus gland organoids (FVB/n) | Oestrogen-independent effects: dysregulation of proteins involved in apoptosis, cell adhesion, and proliferation. | iTRAQ labelling and LC-MS/MS | [70] | |
| PCDD | Sus domesticus cells (granulosa from AVG-16 line) | Affects ovarian follicle fate by reorganising the cytoskeleton and extracellular matrix and modulating proteins important for the cellular response to stress. | 2D-DIGE and MALDI-TOF/TOF | [71] |
| Sus domesticus cells (granulosa from AVG-16 line) | Alteration of three proteins by an AhR-independent mechanism: PDI, ATPbeta, and AnxA5. | 2D-DIGE and MALDI-TOF/TOF | [72] | |
| Rattus norvegicus (Sprague-Dawley) | Upregulation of six testicular proteins involved in stress response and downregulation of SP22, a potential biomarker to diagnose human infertility in dioxin-exposed men. | 2D-DIGE and MALDI-TOF/TOF | [73] | |
| Rattus norvegicus (Sprague-Dawley) | Disruption of ovarian and endocrine functions by dysregulated proteins involved in stress response. | 2D-DIGE and MALDI-TOF/TOF | [74] | |
| BDE-47 | Rattus norvegicus (Sprague-Dawley) | Disruption of spermatogenesis: dysregulated proteins involved in apoptosis and mitochondrial function. | 2D-DIGE and MALDI-TOF/TOF | [75] |
| Mus musculus (C57BL/6J) | Affects male reproduction: dysregulation of proteins involved in stress response, cell maintenance, and inflammatory response. | iTRAQ labelling and nanoLC-MS/MS | [76] | |
| DDT | Homo sapiens cells (NES2Y) | Dysregulated proteins involved in stress response, mitochondrial process, cytoskeletal process, and cell maintenance. | 2D-DIGE and MALDI-TOF/TOF | [7] |