Table 5.

Articles describing POP-induced immunotoxicity.

Molecule	Species	Consequences	Technique	Article
PCDD	Rattus norvegicus (Sprague-Dawley)	Stimulation of immune system: increase in cytokeratin 8 polypeptide, Ig lambda-1 chain C region, and Ig lambda-2 chain C region.	2D-DIGE and MALDI-TOF or nanoLC-MS/MS	[83]
	Callithrix jacchus	Dysregulation of proteins involved in oxidative stress and cytoskeleton maintenance.	2D-DIGE and LC-MS/MS	[42]
	Rattus norvegicus cells (MSC)	Affects osteoblast differentiation by altering their cell architecture, adhesive properties, and calcium homeostasis.	2D-DIGE and LC-MS/MS	[84]
	Homo sapiens cells (hEpB, hEpE and SIK)	Decreases in the differentiation keratinocyte markers: filaggrin, keratin 1, and keratin 10.	2D-DIGE and LC-MS/MS	[85]