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. 2022 Oct 26;12(11):1028. doi: 10.3390/metabo12111028

Figure 6.

Figure 6

MiRNA-216a-5p directly targeted TLR4 mRNA: (A) The predicted TLR4-targeting miRNAs and their binding sites to the 3′-untranslated region (3′ UTR) of TLR4; (B) Relative levels of the predicted miRNAs in Caco-2 cells treated with 6-shogaol in the presence and absence of PA; (C) Relative expression of miR-216a-5p in Caco-2 cells transfected with miR-216a-5p mimics or inhibitor; (D) Effects of miR-216a-5p on the level of TLR4 mRNA. Data are given as means ± standard deviations (n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001.