Table 3.
Oral organisms associated with colorectal cancer (CRC).
| Subject | Organisms (Oral Bacteria) | Sample Type | Reference |
|---|---|---|---|
| 1165 cases with CRC and 739 cases for the periodontal bone loss. | Oral bacteria such as Fusobacteria were enriched in stool samples of CRC patients. | tissue sample | [92] |
| Matching samples of unstimulated saliva, cancer tissues or biopsies and stools were collected from 30 CRC and 30 HC patients. | The proportion of Salivary Firmicutes-to-Bacteroides ratio was higher in the disease group than it was in the control group. | unstimulated saliva, cancer tissues, or biopsies and stool samples | [93] |
| Individuals with either CRC (n = 99), colorectal polyps (n = 32) or healthy individuals as controls (n = 103). | Oral bacteria such as Fusobacterium, Peptostreptococcus, Porphyromonas, and Micromonas were enriched in the stool of patients with CRC or adenomas. |
oral swabs, colonic mucosa, and stool samples | [94] |
| 252 healthy and advanced CRC subjects. |
Oral bacteria such as F. nucleatum, Peptostreptococcus
stomatis, Gemella morbillorum, and Parvimonas micra were enriched in fecal samples of CRC patients. |
fecal sample | [95] |
| Saliva samples from 14 CRC patients were collected. | The proportion of F. nucleatum was higher in the disease group than it was in the control group. | saliva samples | [96] |
| Individuals including 231 incident CRC cases and 462 controls. | The proportion of Bifidobacteriaceae was higher in the disease group than it was in the control group. |
mouth rinse samples |
[97] |
| Populations including CRC (99 subjects), colorectal polyps (32), or controls (103). |
The proportions of Haemophilus, Micromonas, Prevotella, Heterobacterium, Anaerobic, Neisseria, and Streptococcus were lower in the disease group than they were in the control group. |
oral swabs, colonic mucosal and stool samples | [98] |
| Mucosal samples from 59 patients undergoing surgery for CRC, 21 individuals with polyps and 56 healthy controls. |
Bacteroidetes Cluster 1 and Firmicutes Cluster 1 were reduced in fecal samples of CRC patients, whereas Bacteroidetes Cluster 2, Firmicutes Cluster 2, Pathogen Cluster and Prevotella Cluster were enriched in them. |
fecal and mucosal samples | [99] |
| Fecal microbiota in patients with adenomas (n = 233) and those without adenomas (n = 547) were analyzed. |
Pro-inflammatory bacteria of the genera Biliophilus, Desulfovibrio, Mogibacterium and various Bacteroidetes were enriched in fecal samples of CRC patients. |
fecal sample | [100] |