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Five central gene clusters of the GCK–osteoporosis PPI network identified based on MCODE analysis.
| Cluster | Nodes | Edges | Score | Genes |
|---|---|---|---|---|
| 1 | 11 | 36 | 7.200 | SYK; STAT3; PLCG1; PIK3CD; PIK3CB; MAP2K1; JAK1; IL2; HSP90AA1; HCK; GRB2 |
| 2 | 15 | 40 | 5.714 | S1PR1; PSENEN; PSEN2; PSEN1; PIK3R1; PIK3CA; NCSTN; KDR; JAK2; FGF2; FGF1; FES; EPHB4; APH1B; APH1A; |
| 3 | 5 | 10 | 5.000 | RXRG; RXRB; RARB; HDAC3; HDAC1 |
| 4 | 11 | 20 | 4.000 | VEGFB; VEGFA; THBS1; SRC; SERPING1; PTPN1; MAPK8; KIT; IGF1R; CFD; AR |
| 5 | 3 | 3 | 3.000 | MMP9; MMP3; MMP1 |
