Table 2.

Top 20 key genes of the GCK–osteoporosis PPI network identified through the Betweenness, BottleNeck, Degree, Closeness, MCC and EcCentricity method based on cytoHubba tool.

Methods	Betweenness		BottleNeck		Degree		Closeness		MCC		EcCentricity
	Gene	Score	Gene	Score	Gene	Score	Gene	Score	Gene	Score	Gene	Score
1	STAT3	1858.83	PIK3R1	32.00	PIK3R1	35.00	PIK3R1	60.00	PIK3R1	33,711.00	PIK3CA	0.32
2	PIK3R1	1514.88	STAT3	17.00	PIK3CA	34.00	PIK3CA	59.33	PIK3CA	33,710.00	PIK3R1	0.32
3	PIK3CA	1166.88	MMP9	12.00	STAT3	30.00	STAT3	57.08	GRB2	23,136.00	MMP9	0.24
4	EPHB4	1159.36	GRB2	9.00	SRC	23.00	SRC	52.00	PIK3CB	22,560.00	HCK	0.24
5	VEGFA	568.08	EPHB4	8.00	GRB2	22.00	GRB2	51.75	PLCG1	21,770.00	SYK	0.24
6	MTOR	477.35	VEGFA	7.00	PLCG1	21.00	VEGFA	50.17	JAK1	20,934.00	PTPN6	0.24
7	PLCG1	449.22	MAPK14	6.00	VEGFA	20.00	JAK2	49.67	SYK	17,220.00	IGF1R	0.24
8	CCND1	400.60	MTOR	4.00	JAK2	19.00	PLCG1	49.08	HCK	16,812.00	PIK3C2B	0.24
9	MAPK14	384.62	KIT	4.00	JAK1	19.00	JAK1	49.08	SRC	11,096.00	MAP2K1	0.24
10	JAK2	377.93	S1PR1	4.00	IL2	17.00	IL2	48.42	JAK2	10,906.00	STAT3	0.24
11	MMP2	328.71	PTPN6	3.00	PIK3CB	17.00	HSP90AA1	46.42	IL2	8767.00	MTOR	0.24
12	KIT	317.35	MAP2K1	3.00	SYK	15.00	PIK3CB	46.00	STAT3	7819.00	JAK2	0.24
13	IL2	299.91	JAK2	3.00	KDR	15.00	KDR	46.00	PIK3CD	7440.00	MMP1	0.24
14	SRC	296.80	PPARG	3.00	PTPN6	14.00	PTPN6	45.42	MAP2K1	5929.00	PIK3CD	0.24
15	MMP9	262.75	RARB	3.00	MAPK14	14.00	HCK	45.33	KDR	2580.00	MMP3	0.24
16	HDAC3	260.66	CHEK1	3.00	HCK	13.00	KIT	45.00	VEGFA	2392.00	VEGFA	0.24
17	S1PR1	237.33	MMP2	3.00	HSP90AA1	13.00	SYK	44.92	S1PR1	1538.00	KIT	0.24
18	GRB2	225.02	F10	3.00	MAP2K1	12.00	MAPK14	44.87	FGF2	1344.00	PTPN1	0.24
19	PTPN6	212.20	KDR	3.00	S1PR1	12.00	MAP2K1	44.75	HSP90AA1	1130.00	ANXA1	0.24
20	MAP2K1	205.76	HDAC3	3.00	MMP9	11.00	FGF2	44.75	EPHB4	724.00	GNRHR	0.24