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. 2022 Nov 16;27(22):7924. doi: 10.3390/molecules27227924

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The mechanism of antioxidant and anti-inflammatory properties of hemp bioactive peptides on NF-κB and Keap1-Nrf2 signaling pathway. ROS, reactive oxygen species; IKKβ, inhibitor of κB Kinase β; NF-κB, Nuclear Factor κB; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; ARE, antioxidant response elements; CAT, catalase; SOD, superoxide dismutase; GPx, glutathione peroxidase; HO-1, Heme Oxygenase-1; P, TNF, tumor necrosis factor; IL, interleukin, phosphorylation; represents promote or active; represents inhibit or inactive.

Inline graphic — The mechanism of antioxidant and anti-inflammatory properties of hemp bioactive peptides on NF-κB and Keap1-Nrf2 signaling pathway. ROS, reactive oxygen species; IKKβ, inhibitor of κB Kinase β; NF-κB, Nuclear Factor κB; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; ARE, antioxidant response elements; CAT, catalase; SOD, superoxide dismutase; GPx, glutathione peroxidase; HO-1, Heme Oxygenase-1; P, TNF, tumor necrosis factor; IL, interleukin, phosphorylation; represents promote or active; represents inhibit or inactive.