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Effect of VH-4 and exercise training on AMPKα1, Sirt1, PGC1α, and FoX3α signaling pathway in SHR animals. (A) Western blot of AMPKα1, Sirt1, PGC1α, and FoX3α. (B) Graph showing densitometric analysis. *** p < 0.001 compared to WKY, ### p < 0.001 compared to SHR, and † p < 0.05 compared to SHR + EX and/or SHR + VH-4.
