Table 2.
Each natural plant for improving hair loss.
| Chemical Name (Active Material) |
Cell or Animal Type | Working Concentration | Molecular Targets or Effects |
References |
|---|---|---|---|---|
| Aconitie ciliare tuber | Human immortalized DPCs RvDP C57BL/6 mice |
5–50 μg/mL 10 mg/mL |
↑ Wnt/β-catenin ↑ ALP |
[60] |
| Centipeda minima (L.) (CMX) A. Braun and Asch | Human DPCs | 0–12.5 μg/mL | ↑ Wnt5a, Frizzled, VEGF ↑ ERK, JNK |
[61] |
|
Ginkgo biloba extract (Ginkgolide B and bilobalide) |
Human DPCs | 0–100 μM | ↑ Akt, ERK ↑ β-catenin ↓ DKK1 |
[62,63,64] |
|
Malva verticillata (Linoleic acid and oleic acid in n-hexane) |
Human DPCs | 20 μg/mL | ↑ Wnt/β-catenin ↑ IGF-1, KGF, ↑ VEGF, HGF ↓ DKK1 |
[65,66] |
|
Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum, and Fagraea berteroana |
Human DPCs | 0–12.5 μg/mL | ↑ Wnt/β-catenin ↓ DKK1, TGF β |
[67] |
| Polygonum multiflorum extract | C57BL6/N mice | 4.7 mg/12 cm2 | ↑ Shh ↑ β-catenin |
[68,69] |
| Prunus mira Koehne | C57BL/6 mice | Crude oil 15.06–60.26 mg/cm2/day | ↑ Wnt 10b/β-catenin | [70] |
| Red ginseng oil (RGO) |
C57BL/6 mice | 10% | ↑ Wnt/β-catenin ↑ Lef-1, Shh/Gli1 ↑ Cyclin D1, E ↓ TGF-β |
[71] |
| Salvia plebeia (SP) R. Brown (Labiatae) | Human DPCs C57BL/6 mice |
0–31.3 μg/mL 1000 μg/mL |
↑ Wnt/β-catenin ↑ Akt, ERK ↑ HGF ↓ TGFβ, SMAD2/3 |
[72] |
| Shallot (Allium ascalonicum L.) | Human DPCs | 0.1 mg/mL | ↑ Wnt/β-catenin ↑ VEGF ↑ Shh, SMO, Gil1 |
[73] |
| Thuja orientalis | C57BL6/N mice | 5.05 mg/12 cm2/day | ↑ Wnt/β-catenin ↑ Shh |
[74] |
| Watercress | Ex vivo organ culture of human hair follicles 44 male subjects with AGA |
2% WCE-containing Lotion (twice daily for 6 months) | ↑ R-spondin 1 ↓ DKK1 ↑ hair thickness (diameter) ↑ hair density |
[75] |
Dermal papillar cells (DPCs), Sonic hedgehog (Shh), Rat vibrissa dermal papilla cells (RvDP), Red ginseng oil (RGO), Keratinocyte growth factor (KGF), Hepatocyte growth factor (HGF), Vascular endothelial growth factor (VEGF), Insulin growth factor (IGF-1), “↑” increased; “↓” decreased.