Figure 5.

Summary of the effect of CpG island methylation as a result of pathogen infection. (A): Pathogens come into contact with the infected host cell, leading to events that cause hypermethylation of the CpG island to occur. Methylation of CpG islands of the promoter results in TSG silencing and uncontrolled cell proliferation, thus inducing gastric cancer. “X” represents the inhibition of TSG activation. (B): In the absence of pathogens, normal methylation takes place. Cell division is under surveillance as normal transcription continues and TSGs are expressed. Me - methylation, TSG - tumor suppressor gene. Created with BioRender.com. (accessed on 27 September 2022).