Table 1.

Different types of GC molecular classifications.

Classification	Subtypes	Prognosis	Associated Genes	Ref.
Intrinsic subtypes	G- INT	Better overall survival	FUT, LGALS4, CDH17	[20]
	G-DIF	Poor	AURKB, ELOVL5
Lei subtypes	Proliferative	Short disease-free survival	TP53	[22]
	Metabolic		TP53
	Mesenchymal		TP53
TCGA	EBV- positive	Best	PIK3CA, JAK2, PD-L1/2, BCOR	[23]
	MSI	Moderate with no adjuvant chemotherapy response	PIK3CA, ERBB2/3, EGFR, PD-L1, MLH1, TP53
	GS	Worse	CDH1, RHOA
	CIN	Moderate	SMAD4, APC, TP53
ACGA	MSI- high	Best with lowest recurrence frequency	ARID1A, MTOR, KRAS, PIK3CA, ALK, PTEN	[24]
	MSS/EMT	Worse with highest recurrence frequency	CDH1
	MSS/TP53+	Moderate	APC, ARID1A, KRAS, PIK3CA, SMAD4
	MSS/TP53-	Moderate	ERBB2, EGFR, CCNE1, CCND1, MDM2, ROBO2, GATA6, MYC
Combined TCGA and ACRG	EBV- positive	Best	PIK3CA, JAK2, PD-L1/2, BCOR	[25,26]
	MSI- high	Best with lowest recurrence frequency	ARID1A, MTOR, KRAS, PIK3CA, ALK, PTEN
	GC with aberrant E-cadherin	*	*
	GC with aberrant p53 expression	*	*
	GC with normal p53 expression	*	*
CIMP	CIMP-H	*	EBV-associated	[27,28,29,30,31]
	CIMP-L	*	*
	CIMP-N	Worse survival	*

Abbreviations: genomic instability (G-INT), genomic diffuse (G-DIF), chromosomal instability (CIN), genomic stable (GS), microsatellite instability (MSI) and Epstein- Barr virus (EBV), microsatellite stable/epithelial-mesenchymal transition (MSS/EMT), CpG island methylator phenotype-High/Low/Negative (CIMP-H/L/N), not clearly established (*), increased () and decreased () mutations.